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Effect of diet on caffeine elimination in healthy infants
Author(s) -
Blake M. J.,
AbdelRahman S. M.,
Kearns G. L.
Publication year - 2004
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2003.11.188
Subject(s) - caffeine , medicine , urine , cyp1a2 , metabolite , infant formula , physiology , pediatrics , metabolism , cytochrome p450
This study was designed to assess the impact of infant diet on the acquisition of CYP1A2 activity in healthy infants as measured by caffeine (CAF) elimination. Methods: Neonates were seen at 2 wk, 1, 2, 3, 4 and 6 mo where they received oral CAF (7 mg/kg). Serum CAF concentrations were assessed on alternating visits for estimation of CAF elimination rate constant (k e ). Urine was collected for 24 hr following dosing for metabolite determination. Results: To date, 33 infants have been enrolled with18 having completed all 6 study visits. Substantial inter‐individual variation in CAF k e was observed at 2 wks (0.013±0.009 hr −1 ) that appeared unrelated to post‐conceptional age, diet, gender, or tobacco smoke exposure. A marked increase in CAF k e was observed between 2 wks (0.011 hr −1 95%CI [0.009,0.014]) and 8 wks (0.027 hr −1 [0.018,0.040]) postnatal age (P<0.001) and continued to increase at subsequent visits. CAF k e was not different between breast‐ (BF) and formula‐fed (FF) infants at their first study visit but was significantly greater in FF infants (0.038 hr −1 [0.027,0.054]) vs BF (0.013 hr −1 [0.007,0.029]) infants at 8 weeks postnatal age (p = .011). Conclusions: 1) The form of infant feeding appears to alter the developmental profile for CYP1A2 expression (as reflected by CAF elimination). 2) Accelerated caffeine elimination in FF as opposed to BF infants supports a role for dietary modulation of CYP1A2 activity in healthy infants. Clinical Pharmacology & Therapeutics (2004) 75 , P50–P50; doi: 10.1016/j.clpt.2003.11.188