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Statistical estimation of the minimum drug concentration at the steady state when the assay result is below the lower limit of quantitation
Author(s) -
Chiu Y.,
Burt D.,
Hosmane B.,
Bertz R. J.
Publication year - 2004
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/j.clpt.2003.11.157
Subject(s) - limit (mathematics) , estimation , chromatography , steady state (chemistry) , statistics , mathematics , chemistry , mathematical analysis , economics , management
In clinical studies it is common to assess the minimum drug concentration (C min ) in blood at the steady state. However it is not uncommon to have a small number of assay results that are below the lower limit of quantitation (LLOQ). While the 0