Averaging of results derived from different, simultaneously acquired mass transitions in ID-LC-MS/MS – Potential impact on measurement imprecision | Zendy

Carina Schuster | Zendy; Katharina Habler | Zendy; Michael Vogeser | Zendy

Open Access

Averaging of results derived from different, simultaneously acquired mass transitions in ID-LC-MS/MS – Potential impact on measurement imprecision

Author(s) -

Carina Schuster,

Katharina Habler,

Michael Vogeser

Publication year - 2020

Publication title -

clinical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.473

H-Index - 8

eISSN - 2376-9998

pISSN - 2213-8005

DOI - 10.1016/j.clinms.2020.06.001

Subject(s) - analyte , mass spectrometry , chemistry , chromatography , analytical chemistry (journal) , biological system , mathematics , biology

LC-MS/MS allows for many measurands monitoring different mass transitions simultaneously. So far, such alternative mass transitions are usually assessed as "quantifier and qualifier ions" in order to rule out interferences in individual samples. However, quantification can also be based on assessment of alternative mass transitions for both the measurand and its internal standard, with two distinct results for one injection of an individual sample. These paired results can be averaged. The aim of this study was to determine the potential impact of this averaging approach on measurement imprecision.

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