Association of cystatin C proteoforms with estimated glomerular filtration rate | Zendy

Olgica Trenchevska | Zendy; Juraj Koška | Zendy; Shripad Sinari | Zendy; Hussein N. Yassine | Zendy; Peter D. Reaven | Zendy; Dean Billheimer | Zendy; Randall W. Nelson | Zendy; Dobrin Nedelkov | Zendy

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Association of cystatin C proteoforms with estimated glomerular filtration rate

Author(s) -

Olgica Trenchevska,

Juraj Koška,

Shripad Sinari,

Hussein N. Yassine,

Peter D. Reaven,

Dean Billheimer,

Randall W. Nelson,

Dobrin Nedelkov

Publication year - 2016

Publication title -

clinical mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.473

H-Index - 8

eISSN - 2376-9998

pISSN - 2213-8005

DOI - 10.1016/j.clinms.2016.11.001

Subject(s) - renal function , cystatin c , kidney disease , chemistry , type 2 diabetes , medicine , urology , endocrinology , diabetes mellitus

Cystatin C (CysC), a marker for chronic kidney disease, exists as three sequence proteoforms, in addition to the wild-type sequence: one contains hydroxyproline at position 3 (3Pro-OH), the two others have truncated sequences (des-S and des-SSP). Here, we examine correlations between each of these CysC proteoforms and estimated glomerular filtration rate (eGFR), a diagnostic criterion for chronic kidney disease (CKD).

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