Open AccessBacterial resistance in acne? A meta-analysis of the controversy
Author(s) -
M. E. Álvarez-Sánchez,
Ernesto Rodríguez-Ayala,
Rosa María Ponce-Olivera,
Andrés TiradoSánchez,
María Ivonne Arellano-Mendoza
Publication year - 2016
Publication title -
cirugía y cirujanos
Language(s) - English
Resource type - Journals
ISSN - 2444-0507
DOI - 10.1016/j.circen.2016.04.003
Subject(s) - propionibacterium acnes , medicine , erythromycin , clindamycin , acne , benzoyl peroxide , dermatology , antibiotics , incidence (geometry) , propionibacterium , antibiotic resistance , microbiology and biotechnology , bacteria , biology , polymer , chemistry , physics , genetics , organic chemistry , optics , polymerization
BackgroundAcne is one of the dermatological pathologies with the highest incidence around the world. It is a multifactorial disease and its treatment can be complex. Propionibacterium acnes play a key role in the inflammation of this dermatosis. Topical antibiotics, including mainly erythromycin and clindamycin, have been used, but there is controversy over their use due to the widely documented bacterial resistance. For this reason a meta-analysis of the publications over the past 10 years is presented in order to confirm this hypothesis.Material and methodsA search was made of the publications over the past 10 years that included the results of antibiogams of patients with acne. MeSH type searches were performed with the terms “acne vulgaris”, “Propionibacterium acnes”, “topical administration”, “treatment”, “erythromycin”, “clindamycin”, “nadifloxacin”, “antibacterial agent”, “bacterial drug resistance” in PubMed, Ovid, EBSCO, Cochrane, ScienceDirect and ClinicalKey meta-searches.ResultsA total of 13 articles were found that met the inclusion criteria. The mean odds ratio (OR 1.24, 95% CI) of the articles showed a slight tendency towards resistance of P. acnes.ConclusionsAn increase in bacterial resistance to topical erythromycin and clindamycin can be confirmed, thus the use of these antibiotics is recommended in selective cases for short periods, and in combination with benzoyl peroxide for the best clinical outcome in patients with acne vulgaris