Premium
TNF superfamily: Costimulation and clinical applications
Author(s) -
Vinay Dass S.,
Kwon Byoung S.
Publication year - 2009
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2009.02.001
Subject(s) - immunoglobulin superfamily , superfamily , tumor necrosis factor alpha , tumor necrosis factor receptor , immunology , receptor , biology , microbiology and biotechnology , antibody , cancer research , genetics
The molecules concerned with costimulation belong either to the immunoglobulin (Ig) or tumor necrosis factor (TNF) superfamily. The tumor necrosis superfamily comprises molecules capable of providing both costimulation and cell death. In this review we briefly summarize certain TNF superfamily receptor–ligand pairs that are endowed with costimulatory properties and their importance in health and disease.