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Licochalcone A inhibits the formation and bone resorptive activity of osteoclasts
Author(s) -
Kim Soon Nam,
Kim Myung Hee,
Min Yong Ki,
Kim Seong Hwan
Publication year - 2008
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2008.04.017
Subject(s) - rankl , chemistry , bone resorption , osteoclast , microbiology and biotechnology , macrophage colony stimulating factor , acid phosphatase , activator (genetics) , receptor , biochemistry , endocrinology , biology , macrophage , in vitro , enzyme
Licochalcone A on the formation and bone resorptive activity of osteoclasts up to 5 μM significantly inhibited the receptor activator of nuclear factor κB (NF‐κB) ligand (RANKL)‐induced activity of tartrate‐resistant acid phosphatase (TRAP) activity and formation of osteoclasts without any effect on cell viability. Interestingly, licochalcone A was shown to inhibit the RANKL‐induced activation of extracellular signal‐regulated kinase, translocation of NF‐κB into nucleus and mRNA expression of Fra‐2. Licochalcone A also inhibited the bone resorptive activity of mature osteoclasts and the expression of bone resorption‐related genes. Inhibitory effects of licochalcone A on the formation and bone resorptive activity of mouse bone marrow macrophage‐derived osteoclasts were also observed. In conclusion, licochalcone A has the potential to inhibit the formation of osteoclasts as well as the bone resorptive activity of mature osteoclasts.