Premium
G‐protein‐coupled receptor Gpr1 and G‐protein Gpa2 of cAMP‐dependent signaling pathway are involved in glucose‐induced pexophagy in the yeast Saccharomyces cerevisiae
Author(s) -
Nazarko Volodymyr Y.,
Thevelein Johan M.,
Sibirny Andriy A.
Publication year - 2008
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2007.11.001
Subject(s) - saccharomyces cerevisiae , yeast , peroxisome , signal transduction , g protein , microbiology and biotechnology , biology , thiolase , biochemistry , receptor , g protein coupled receptor
In yeast cell, glucose induces various changes of cellular metabolism on genetic and metabolic levels. One of such changes is autophagic degradation of dispensable peroxisomes (pexophagy) which occurs in vacuoles. We have found that in Saccharomyces cerevisiae , defect of G‐protein‐coupled receptor Gpr1 and G‐protein Gpa2, both the components of cAMP‐signaling pathway, strongly suppressed glucose‐induced degradation of matrix peroxisomal protein thiolase. We conclude that proteins Gpr1 and Gpa2 are involved in glucose sensing and signal transduction during pexophagy process in yeast.