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Effect of sildenafil citrate (Viagra) and ethanol on the Albino rat testis: A scanning electron microscopic approach
Author(s) -
Sivasankaran T.G.,
Udayakumar R.,
Elanchezhiyan C.,
Sabhanayakam Selvi
Publication year - 2008
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2007.10.006
Subject(s) - sildenafil , ethanol , saline , scanning electron microscope , physiological saline , chemistry , endocrinology , dose dependence , body weight , adult male , medicine , pharmacology , biochemistry , materials science , composite material
The effects of sildenafil citrate with ethanol on the rat testis was studied using scanning electron microscopy. Male Albino rats were divided into 8 groups, each being treated for a maximum of 45 days as follows. In the 4 short‐term treatment groups, control rats were administered normal saline orally, whereas experimental animals were fed sildenafil citrate (Viagra) 1 μg/g with 18% ethanol (5 g/kg body weight), which was given orally as a single dose. After 1, 2.5, 4 and 24 h the rats were killed. In the 4 long‐term treatment groups, daily continuous doses of drug and ethanol with a single dosage were given for 15, 30 and 45 days and the animals killed 4 h after the last dosage. Changes in the testis were compared with the normal healthy rat testis. The use of a scanning electron microscope for evaluation of the changes in the testis is more suitable for observation of the surface and morphological shapes of the tissue structures.