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Post‐conditioning exacerbates the MnSOD immune‐reactivity after experimental cerebral global ischemia and reperfusion in the rat brain hippocampus
Author(s) -
Nemethova Miroslava,
Danielisova Viera,
Gottlieb Miroslav,
Burda Jozef
Publication year - 2008
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2007.08.023
Subject(s) - dentate gyrus , hippocampus , ischemia , conditioning , immune system , neuroscience , brain ischemia , reactivity (psychology) , gyrus , medicine , chemistry , biology , pathology , immunology , statistics , alternative medicine , mathematics
This study monitored the effects of sub‐lethal ischemia (post‐conditioning) applied after a previous ischemic attack by way of the MnSOD immune‐reactivity examined in CA1 and dentate gyrus of the rat hippocampus. The experimental 10 min transient cerebral ischemia was followed by 2 days of reperfusion, the rats then underwent a second ischemia (4 or 6 min post‐conditioning). MnSOD immune‐reactivity was evaluated after 5 h, 1 and 2 days. Results obtained by computer microdensitometric image analysis indicated that 4 min of ischemic post‐conditioning caused higher MnSOD immune‐reactivity than 6 min. However, higher viability of CA1 neurons after stronger (6 min) post‐conditioning when production of MnSOD is lower, as well as differences between MnSOD in CA1 and dentate gyrus indicates another mechanism switching pro‐apoptotic destination of CA1 neurons to anti‐apoptotic.