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Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice
Author(s) -
Otaki Sayuri,
Ueshima Shigeru,
Shiraishi Kohei,
Sugiyama Kazuo,
Hamada Suguru,
Yorimoto Masatomo,
Matsuo Osamu
Publication year - 2007
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2007.04.001
Subject(s) - mesenchymal stem cell , odontoblast , dental pulp stem cells , pulp (tooth) , microbiology and biotechnology , stem cell , progenitor cell , stem cell transplantation for articular cartilage repair , tissue engineering , extracellular matrix , bone marrow , adult stem cell , chemistry , immunology , biology , dentistry , in vitro , biomedical engineering , medicine , endothelial stem cell , biochemistry
The technique of tissue engineering is developing for the restoration of lost tissues. This new technique requires cells that fabricate tissue. Mesenchymal stem cells in bone marrow have been used as the cell source for this technique; however, dental pulp cells have recently been shown to possess stem‐cell‐like properties. We earlier demonstrated that dental pulp cells proliferate and produce an extracellular matrix that subsequently becomes mineralized in vitro . We now report that such dental pulp cells (first to eighth passage) produced bone instead of dentin when those cells were implanted into subcutaneous sites in immunocompromised mice with HA/TCP powder as their carrier. This evidence shows that dental pulp cells are the common progenitors of odontoblasts and osteoblasts, or dental pulp cells are mesenchymal stem cells themselves. It is expected that dental pulp cells can be a useful candidate cell source for tissue engineering, and contain the potential of new therapeutic approaches for the restoration of damaged or diseased tissue.