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Lack of effect of dopaminergic antagonists in a rodent model of peritoneal sepsis
Author(s) -
Machado Roberta Albino,
Constantino Larissa,
Martins Márcio Rodrigo,
Albuquerque Isabella Martins,
MennaBarreto Sérgio,
Streck Emílio,
Quevedo João,
DalPizzol Felipe
Publication year - 2007
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2007.03.022
Subject(s) - haloperidol , sepsis , clozapine , medicine , pharmacology , immunology , dopamine , schizophrenia (object oriented programming) , psychiatry
Central nervous system dopaminergic mechanisms have been implicated in the cytokine response to stress and sepsis. We here describe the effects of haloperidol or clozapine in the treatment of sepsis induced by cecal ligation and puncture. Male Wistar rats were subjected to the CLP procedure were treated with haloperidol or clozapine and plasma cytokines, myeloperoxidase activity, markers of organ injury and survival was analyzed. The addition of haloperidol or clozapine to basic support did not diminished hepatic, renal, pancreatic or muscular damage observed after sepsis. Neither haloperidol, nor clozapine, modulates pro and antiinflammatory cytokines after sepsis induction. In addition, haloperidol treatment did not diminished myeloperoxidase activity in the kidney, lung or liver, or altered BALF markers of lung damage or inflammatory infiltration. Our data did not support a role of haloperidol or clozapine as an immunomodulator agent in the treatment of sepsis in an animal model of peritonitis.