Neuroprotective effects of tetramethylpyrazine on hydrogen peroxide‐induced apoptosis in PC12 cells | Zendy

Cheng XinRui | Zendy; Zhang Li | Zendy; Hu JuanJuan | Zendy; Sun Lan | Zendy; Du GuanHua | Zendy

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Neuroprotective effects of tetramethylpyrazine on hydrogen peroxide‐induced apoptosis in PC12 cells

Author(s) -

Cheng XinRui,

Zhang Li,

Hu JuanJuan,

Sun Lan,

Du GuanHua

Publication year - 2007

Publication title -

cell biology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.932

H-Index - 77

eISSN - 1095-8355

pISSN - 1065-6995

DOI - 10.1016/j.cellbi.2006.10.001

Subject(s) - cytochrome c , apoptosis , tetramethylpyrazine , hydrogen peroxide , chemistry , cytosol , caspase , neuroprotection , microbiology and biotechnology , caspase 9 , caspase 3 , biochemistry , programmed cell death , biology , pharmacology , enzyme , medicine , alternative medicine , pathology

In the present study, we investigated the effects of tetramethylpyrazine (TMP) on hydrogen peroxide (H 2 O 2 )‐induced apoptosis in PC12 cells. The apoptosis in H 2 O 2 ‐induced PC12 cells was accompanied by a decrease in Bcl‐2/Bax protein ratio, release of cytochrome c to cytosol and the activation of caspase‐3. TMP not only suppressed the down‐regulation of Bcl‐2, up‐regulation of Bax and the release of mitochondrial cytochrome c to cytosol, but also attenuated caspase‐3 activation and eventually protected against H 2 O 2 ‐induced apoptosis. These results indicated that TMP blocked H 2 O 2 ‐induced apoptosis by the regulation of Bcl‐2 family members, suppression of cytochrome c release, and caspase cascade activation in PC12 cells.

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