Algal toxin yessotoxin signalling pathways involve immunocyte mussel calcium channels | Zendy

Malagoli Davide | Zendy; Casarini Livio | Zendy; Ottaviani Enzo | Zendy

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Algal toxin yessotoxin signalling pathways involve immunocyte mussel calcium channels

Author(s) -

Malagoli Davide,

Casarini Livio,

Ottaviani Enzo

Publication year - 2006

Publication title -

cell biology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.932

H-Index - 77

eISSN - 1095-8355

pISSN - 1065-6995

DOI - 10.1016/j.cellbi.2006.05.003

Subject(s) - mytilus , verapamil , nitric oxide , mussel , toxin , intracellular , chemistry , calcium , marine toxin , biology , biochemistry , ecology , endocrinology , organic chemistry

A fragment of a putative L‐type Ca 2+ channel has been identified by molecular biology experiments in immunocytes from the mussel Mytilus galloprovincialis . Using the cell permeable and Ca 2+ ‐specific fluorochrome FURA 2‐AM, we have demonstrated that the algal toxin yessotoxin (YTX) is able to increase intracellular Ca 2+ concentration in M. galloprovincialis immunocytes. The YTX effect on Ca 2+ increase is inhibited by the L‐type Ca 2+ channel inhibitor, verapamil, which is cAMP‐ and cGMP‐dependent, but PKA‐ and nitric oxide‐independent. On the basis of these observations, a possible role for YTX as a potential disturber of mussel immune efficiency is suggested.

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