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Stromal cell derived factor‐1 acutely promotes neural progenitor cell proliferation in vitro by a mechanism involving the ERK1/2 and PI‐3K signal pathways *
Author(s) -
Gong Xiaoming,
He Xiangping,
Qi Lei,
Zuo Huancong,
Xie Zuoping
Publication year - 2006
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2006.01.007
Subject(s) - wortmannin , microbiology and biotechnology , basic fibroblast growth factor , stromal cell , progenitor cell , signal transduction , biology , neural stem cell , cell growth , cytokine , phosphatidylinositol , fibroblast growth factor , growth factor , receptor , cancer research , immunology , stem cell , biochemistry
Stromal cell derived factor‐1 (SDF‐1), a member of the chemotactic cytokine family, has attracted attention in recent years. It participates in diverse processes such as the regulation of neuronal migration and activation of CD4+ T cells; it is also a co‐receptor for human immunodeficiency virus‐1 (HIV‐1). Here, we show that the proliferation of neural progenitor cells dissociated from rat cortex and cultured in vitro with basic fibroblast growth factor (bFGF) is stimulated by SDF‐1. PD98059 and wortmannin, which are, respectively, specific inhibitors of the extracellular regulated kinase1/2 (ERK1/2) and phosphatidylinositol‐3 kinase (PI‐3K) signal pathways, markedly attenuate this stimulation of proliferation. These findings indicate that SDF‐1 acutely promotes the proliferation of NPCs in vitro involving the ERK1/2 and PI‐3 kinase pathways, suggesting that it plays a basic role in the development of neural progenitors.