Premium
Effects of Ginkgolide on the development of NOS and AChE positive neurons in the embryonic basal forebrain
Author(s) -
Jin GuoHua,
Huang Zhen,
Tan XueFeng,
Tian MeiLing,
Zhang XinHua,
Qin JianBing,
Xu HuiJun,
Yew D.T.,
Mak Y.T.
Publication year - 2006
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2005.12.012
Subject(s) - basal forebrain , forebrain , aché , basal (medicine) , ginkgo biloba , neuroprotection , embryonic stem cell , neurotrophin , neuroscience , biology , medicine , endocrinology , pharmacology , acetylcholinesterase , biochemistry , central nervous system , enzyme , receptor , gene , insulin
Abstract Extract of Ginkgo biloba (EGb) has been therapeutically used for several decades to increase peripheral and cerebral blood flow so as to prevent cardiovascular and neurovascular diseases. However, the role of EGb in neuroprotective effects has received much attention recently. In this study, we investigated the effect of EGb on the development of NOS and AChE positive neurons in the rat embryonic basal forebrain. The results showed that treated with EGb, the OD of MTT staining analysis, and the numbers, the cell sizes and circumferences of NOS and AChE positive neurons were greatly promoted. These data suggest that EGb had similar effects of the neurotrophins such as NGF and BDNF in promoting the development of NOS and AChE positive neurons in the rat embryonic basal forebrain.