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Cytotoxicity, haematotoxicity and genotoxicity of high molecular mass arborescent polyoxyethylene polymers with polyglycidol‐block‐containing shells
Author(s) -
Klajnert Barbara,
Walach Wojciech,
Bryszewska Maria,
Dworak Andrzej,
Shcharbin Dzmitry
Publication year - 2006
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2005.10.026
Subject(s) - ethidium bromide , genotoxicity , haemolysis , polymer , bromide , chemistry , macromolecule , cytotoxicity , in vitro , mtt assay , comet assay , toxicity , dna , dna damage , biochemistry , organic chemistry , biology , immunology
We have examined the impact on biological systems of some newly synthesised polyoxyethylene polymers using in vitro assays. Toxicity was tested by the 3‐[4,5‐dimethylthiazole‐2‐yl]‐2,5 diphenyltetrazolium bromide (MTT) assay, haemolysis was assessed, and an ethidium bromide (EB) assay was used to study interactions between the polymers and DNA. All the assay data showed that the polymers are biocompatible. No differences were found between generations (i.e. macromolecule sizes). The results encourage continuing studies on the clinical use of these molecules as drug carriers.