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Induction of BAALC and down regulation of RAMP3 in astrocytes treated with differentiation inducers
Author(s) -
Moodbidri Madhavi S.,
Shirsat Neelam V.
Publication year - 2006
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2005.10.022
Subject(s) - autocrine signalling , paracrine signalling , biology , astrocyte , microbiology and biotechnology , staurosporine , inducer , cellular differentiation , progenitor cell , cancer research , signal transduction , receptor , neuroscience , protein kinase c , gene , genetics , stem cell , central nervous system
Genes controlling proliferation and differentiation of astrocytes are likely to play an important role in the pathogenesis of astrocytic gliomas and could serve as therapeutic targets. mRNA differential display analysis identified two genes, viz. BAALC and RAMP3 , whose expression is altered in primary astrocytes treated with differentiation inducers. BAALC , which has been reported to be expressed in neural progenitor cells, was found to be up regulated in both normal and malignant astrocytes on inhibition of proliferation. RAMP3 functions as a modulator of the receptor for adrenomedullin (AM). AM has been suggested to act as autocrine/paracrine growth factor for gliomas. Our studies show RAMP3 down regulation on staurosporine treatment of astrocytes, suggesting protein kinase C inhibition as a possible strategy for inhibiting AM activity and thereby growth of glioma cells.