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Patterns of nestin expression in human skin
Author(s) -
Wang Yun,
Zhang Yi,
Zeng Yijun,
Zheng Yehua,
Fu Gang,
Cui Zhihong,
Yang Tian
Publication year - 2006
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2005.09.005
Subject(s) - nestin , expression (computer science) , microbiology and biotechnology , biology , computational biology , computer science , neural stem cell , stem cell , programming language
Nestin, a member of the sixth class of intermediate filament proteins, has long been known not only as a specific marker for central nervous system stem cells, but also as an indicator of the degree of neural stem cell differentiation. Immunohistochemical analysis showed nestin expression in the epidermis and the upper two‐third of the hair follicle in non‐balding human scalp skin, but not in the lower third of the follicle. Expression was very weak in the sebaceous gland. The level of nestin mRNA transcription was much higher in the bulge region of the follicle than in the sebaceous gland. These results show that the pattern of nestin expression is related to the differentiation of epidermal stem cells.