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Osteocalcin is angiogenic in vivo
Author(s) -
Cantatore Francesco Paolo,
Crivellato Enrico,
Nico Beatrice,
Ribatti Domenico
Publication year - 2005
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2005.03.011
Subject(s) - angiogenesis , chorioallantoic membrane , osteocalcin , in vivo , chemistry , microbiology and biotechnology , neovascularization , embryo , endocrinology , medicine , biology , biochemistry , alkaline phosphatase , enzyme
The exact function of osteocalcin (OC), a protein synthesized by osteoblasts during the matrix mineralization phase, is still unknown. In this study we investigated the capacity of OC to promote vasoproliferation in chick embryo chorioallantoic membrane (CAM), a well established in vivo assay for angiogenesis and anti‐angiogenesis. The results showed that OC stimulates angiogenesis and that the response is similar to that obtained with FGF‐2, a well‐known angiogenic cytokine. It has previously been demonstrated that OC is involved in bone repair, so the angiogenic activity reported here might also play a crucial role in bone formation.