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Effects of chronic ethanol treatment on glial fibrillary acidic protein expression in adult rat optic nerve: an immunocytochemical study
Author(s) -
Gonca Süheyla,
Filiz Serdar,
Dalçık Cannur,
Yardımoğlu Melda,
Dalçık Hakkı,
Yazır Yusufhan,
Erden B. Faruk
Publication year - 2005
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2004.11.020
Subject(s) - glial fibrillary acidic protein , astrocyte , optic nerve , gfap stain , central nervous system , chemistry , pathology , protein expression , endocrinology , biology , immunohistochemistry , medicine , anatomy , biochemistry , gene
Glial fibrillary acidic protein (GFAP) is used as a marker of astrocyte response to various central nervous system injuries. In the present study, the effects of chronic ethanol administration on GFAP immunoreactivity were evaluated in astrocytes of the adult optic nerve head. The results demonstrated that ethanol exposure significantly and dramatically increases GFAP immunoreactivity and the number of immunoreactive astrocytes (p<0.001). In addition, GFAP immunoreactive cells in the optic nerve showed extensive hypertrophy (p<0.001).