Premium
Increased frequency of sister chromatid exchanges in peripheral lymphocytes of alcoholics and cigarette smokers
Author(s) -
Karaoğuz Meral Yirmibeş,
Coşar Behçet,
Arıkan Zehra,
Başaran Feride,
Menevşe Adnan,
Menevşe Sevda
Publication year - 2005
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2004.11.019
Subject(s) - sister chromatids , sister chromatid exchange , genotoxicity , cigarette smoking , alcohol consumption , peripheral , medicine , alcohol , physiology , toxicology , chemistry , biology , genetics , toxicity , in vitro , biochemistry , gene , chromosome
Sister chromatid exchange (SCE) is a sensitive indicator of genotoxicity. In this study we investigated the effects of alcohol consumption and cigarette smoking on the frequency of SCE in cultures of peripheral lymphocytes. The rate was higher in alcoholics who smoked (10.89±2.46) and in smokers (positive controls) (7.64±1.01) than in healthy non‐smokers (negative controls) (6.96±2.18). Statistical analysis suggested that the increases were related to alcohol consumption and cigarette smoking (p<0.05).