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Involvement of protein kinases on the process of erythrophagocytis by Entamoeba histolytica
Author(s) -
Batista Evander de J.O,
Souza Wanderley
Publication year - 2004
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2004.01.005
Subject(s) - entamoeba histolytica , staurosporine , wortmannin , microbiology and biotechnology , kinase , virulence , biology , genistein , tyrosine kinase , protein kinase a , biochemistry , signal transduction , phosphatidylinositol , gene , endocrinology
Erythrophagocytic capacity of trophozoites of Entamoeba histolytica is considered a factor in the virulence of this pathogenic protozoan. We present evidence showing that such activity resembles the ingestion of microorganisms by highly differentiated phagocytic cells, such as macrophages. Previous treatment of the trophozoites with genistein or tyrphostin, inhibitors of tyrosine protein kinases, with staurosporine, a protein kinase C inhibitor, and wortmannin, a fungal metabolite that inhibits phosphoinositide 3‐OH kinase, significantly inhibited their erythrophagocytic capacity.