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Leptin‐induced signal transduction pathways
Author(s) -
Hegyi Krisztina,
Fülöp Kristóf,
Kovács Krisztina,
Tóth Sára,
Falus András
Publication year - 2004
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2003.12.003
Subject(s) - leptin , leptin receptor , signal transduction , ampk , jak stat signaling pathway , stat , microbiology and biotechnology , gene isoform , mapk/erk pathway , biology , protein kinase a , endocrinology , medicine , kinase , stat3 , gene , tyrosine kinase , biochemistry , obesity
Leptin is a multifunctional cytokine and hormone that primarily acts in the hypothalamus and plays a key role in the regulation of food intake and energy expenditure. In addition, it has direct effects on many cell types on the periphery. Leptin acts through its receptor, the product of the db gene, which has six isoforms. Only one of them (OB‐Rb) has full signalling capabilities and is able to activate the Jak/STAT pathway, the major pathway used by leptin to exert its effects. However, some signalling events can be initiated by the short isoforms. Besides Jak/STAT, other pathways, such as MAPK and the 5′‐AMP‐activated protein kinase (AMPK) pathway, are also involved in leptin signalling. Leptin also interacts with insulin signalling. In this paper, we give an overview of the signal transduction mechanisms that are related to the actions of leptin.