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Syndecan‐2 expression enhances adhesion and proliferation of stably transfected Swiss 3T3 cells
Author(s) -
Villena Joan,
Berndt Christine,
Granés Francesc,
Reina Manuel,
Vilaró Senén
Publication year - 2003
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1016/j.cellbi.2003.09.004
Subject(s) - syndecan 1 , cell adhesion , adhesion , transfection , microbiology and biotechnology , 3t3 cells , cell growth , cell , chemistry , fibroblast growth factor , heparan sulfate , cell adhesion molecule , extracellular matrix , receptor , biology , biochemistry , gene , organic chemistry
Syndecans (heparan sulfate proteoglycans) participate in cell—cell and cell—matrix adhesion and are co‐ and low‐affinity receptors for growth factors and enzymes, respectively. We examined the influence of stable syndecan‐2 expression in Swiss 3T3 cells on cell‐adhesion and proliferation. Higher syndecan‐2 expression changed cell morphology and increased spreading and adhesion in these cells and proliferation induced by FCS and FGF‐2. This emphasizes the role of syndecan‐2 in the integration of signals from soluble and insoluble factors.