Transcription factor hijacking in the name of tolerance | Zendy

I Rodé | Zendy; HansReimer Rodewald | Zendy

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Transcription factor hijacking in the name of tolerance

Author(s) -

I Rodé,

HansReimer Rodewald

Publication year - 2022

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2022.06.026

Subject(s) - biology , transcription factor , autoimmunity , microbiology and biotechnology , ectopic expression , central tolerance , antigen , gene , immunology , immune tolerance , cancer research , genetics , immune system

Thymus epithelial cells (TECs) express antigens from peripheral tissues to select against autoreactive T cells and thus prevent autoimmunity. Michelsen et al. now show that molecularly defined clusters of thymic epithelial cells express and depend on skin-, lung-, liver- or intestinal-cell transcription factors that are co-opted by the thymus to drive ectopic gene expression.

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