Open AccessBreaking down a gut-to-brain circuit that prevents malabsorption
Author(s) -
Brooke C. Jarvie,
Zachary A. Knight
Publication year - 2022
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2022.06.012
Subject(s) - biology , malabsorption , motility , gut–brain axis , appetite , enteric nervous system , medicine , hypothalamus , endocrinology , gastroenterology , microbiology and biotechnology , gut flora , biochemistry
The ileal brake is an important reflex that ensures proper absorption of nutrients. This involves intestinal GLP-1 release, which recruits an enteric-sympathetic-spinal pathway to inhibit gastric motility and appetite. This visceral alarm system could be targeted to treat obesity and gastrointestinal dysfunction.
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