Shigella “Osp”pression of innate immunity | Zendy

Skylar S. Wright | Zendy; Sivapriya Kailasan Vanaja | Zendy

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Shigella “Osp”pression of innate immunity

Author(s) -

Skylar S. Wright,

Sivapriya Kailasan Vanaja

Publication year - 2022

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2022.05.027

Subject(s) - biology , shigella , effector , innate immune system , immunity , microbiology and biotechnology , pathogen , shigella flexneri , antimicrobial , interferon , mechanism (biology) , immunology , virology , immune system , bacteria , genetics , escherichia coli , salmonella , gene , philosophy , epistemology

Interferons are potent antimicrobial effectors and thus an attractive target for pathogen interference. In this issue of Cell, Alphonse et al. reveal that the Shigella effectors OspC1 and OspC3 employ a surprising mechanism to block interferon signaling and attenuate antibacterial responses, thus securing their replicative niche.

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