Open AccessBacPROTACs to basics: Targeted protein degradation in bacteria
Author(s) -
George M. Burslem
Publication year - 2022
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2022.05.026
Subject(s) - biology , reprogramming , proteases , bacteria , protein degradation , degradation (telecommunications) , computational biology , cell , microbiology and biotechnology , biochemistry , genetics , enzyme , telecommunications , computer science
Targeted protein degradation has emerged as a powerful tool for therapeutic development and biological exploration. In this issue of Cell, Morreale et al. report the development of the BacPROTAC technology to enable targeted protein degradation in Gram-positive bacteria and mycobacteria via reprogramming of Clp proteases.
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