Open AccessTIR domains as two-tiered enzymes to activate plant immunity
Author(s) -
Lei Tian,
Xin Li
Publication year - 2022
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2022.05.025
Subject(s) - biology , immune system , plant immunity , immunity , enzyme , dna , receptor , microbiology and biotechnology , immune receptor , rna , genetics , virology , biochemistry , gene , arabidopsis , mutant
Plant immune receptors often contain TIR domains, which can oligomerize to form active enzyme complexes in response to pathogen infections. In this issue of Cell, Yu and colleagues discover that some plant TIR domains possess a novel 2',3'-cAMP/cGMP synthetase activity that cleaves double-stranded RNA/DNA, triggering cell death during plant immune responses.
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