Flying under the radar: TMEM106B(120–254) fibrils break out in diverse neurodegenerative disorders | Zendy

Katie E. Copley | Zendy; James Shorter | Zendy

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Flying under the radar: TMEM106B(120–254) fibrils break out in diverse neurodegenerative disorders

Author(s) -

Katie E. Copley,

James Shorter

Publication year - 2022

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2022.03.032

Subject(s) - biology , frontotemporal lobar degeneration , fibril , amyloid fibril , neuroscience , disease , degeneration (medical) , neurodegeneration , frontotemporal dementia , amyloid β , biochemistry , pathology , medicine , dementia

Neurodegenerative diseases commonly exhibit aggregation of specific proteins that define each disease. Chang et al. (2022) establish that a C-terminal fragment of TMEM106B, a frontotemporal-lobar-degeneration risk factor, unexpectedly forms amyloid fibrils with similar structures in diverse neurodegenerative disorders. These unanticipated TMEM106B(120-254) fibrils may herald etiological shifts for several neurodegenerative diseases.

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