Open AccessMapping the long road to cancer
Author(s) -
David Cheek,
Kamila Naxerova
Publication year - 2022
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2022.02.020
Subject(s) - biology , cancer , timeline , computational biology , mutation , genome , genetics , evolutionary biology , bioinformatics , gene , archaeology , history
Every cell in our body accumulates mutations throughout life, and sometimes an unfortunate combination of mutations drives the initiation of cancer. A new study infers extraordinarily detailed timelines of pre-cancerous evolution by sequencing single-cell genomes in patients with blood malignancies-finding that key mutations can arrive decades before diagnosis.
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