Open AccessQuo vadis, neutrophil?
Author(s) -
Rodrigo J. Gonzalez,
Ulrich H. von Andrian
Publication year - 2022
Publication title -
cell
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2022.02.009
Subject(s) - biology , inflammation , receptor , metabolite , immunology , platelet , microbiology and biotechnology , platelet activation , serotonin , genetics , biochemistry
Neutrophil recruitment from blood into tissues is a hallmark of inflammation and anti-microbial host defense. In this issue, De Giovanni et al. describe an unanticipated role for a serotonin metabolite, 5-HIAA, which is produced by activated platelets and mast cells and engages the orphan receptor, GPR35, to recruit neutrophils to inflamed tissues.
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