Time matters: Human blastoids resemble the sequence of blastocyst development | Zendy

Ronghui Li | Zendy; Cuiqing Zhong | Zendy; Juan Carlos Izpisúa Belmonte | Zendy

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Time matters: Human blastoids resemble the sequence of blastocyst development

Author(s) -

Ronghui Li,

Cuiqing Zhong,

Juan Carlos Izpisúa Belmonte

Publication year - 2022

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2022.01.005

Subject(s) - biology , blastocyst , induced pluripotent stem cell , embryonic stem cell , microbiology and biotechnology , embryo , computational biology , genetics , embryogenesis , andrology , gene , medicine

In a recent issue of Nature, Kagawa et al. reported a highly efficient and robust protocol for generating human blastoids from naive human pluripotent stem cells. The blastoids resemble human blastocysts, follow the sequential lineage specification of blastocyst development, and can attach to endometrial cells with the polar trophectoderm to model implantation.

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