Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion | Zendy

Mihe Hong | Zendy; Yvonne Y. Chen | Zendy

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Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion

Author(s) -

Mihe Hong,

Yvonne Y. Chen

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.11.015

Subject(s) - biology , chimeric antigen receptor , phenotype , cell , immunology , microbiology and biotechnology , gene , natural killer cell , receptor , antigen , in vitro , cancer research , t cell , cytotoxicity , genetics , immune system

Exhaustion of chimeric antigen receptor (CAR)-T cells hinders their therapeutic efficacy, especially in treating solid tumors. In this issue of Cell, Good et al. develop an in vitro model of antigen-driven CAR-T cell exhaustion to characterize signatures of dysfunction, including a transition to a natural killer (NK)-like phenotype, and suggest new gene targets to prevent exhaustion.

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