Open AccessThe brain remembers where and how inflammation struck
Author(s) -
Nadine Gogolla
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.11.002
Subject(s) - biology , neuroscience , inflammation , immune system , engram , disease , immunological memory , brain disease , cortex (anatomy) , cognitive science , immunology , immunity , psychology , pathology , medicine
Our immune system and brain interact on multiple scales, but how the brain represents and remembers immune challenges remains unclear. In this issue of Cell, Koren et al. (2021) reveal that the brain's insular cortex stores information about inflammation in the body. Strikingly, these immunological "memory engrams" can restore the initial disease state when reactivated.
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