Morpholinos meet mitochondria: Targeting organellar gene expression | Zendy

Heike Rampelt | Zendy; Nikolaus Pfanner | Zendy

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Morpholinos meet mitochondria: Targeting organellar gene expression

Author(s) -

Heike Rampelt,

Nikolaus Pfanner

Publication year - 2021

Publication title -

cell

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.10.019

Subject(s) - biology , mitochondrion , gene silencing , gene , genome , mitochondrial dna , morpholino , gene expression , genetics , function (biology) , microbiology and biotechnology , computational biology , gene knockdown

The mitochondrial genome encodes proteins central to mitochondrial function; however, transcript-specific mechanistic studies of mitochondrial gene products have been difficult because of challenges in their experimental manipulation. Cruz-Zaragoza et al. provide a solution to this challenge, introducing an elegant system for efficient translational silencing of transcripts in human mitochondria.

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