Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine | Zendy

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Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

Author(s) -

Rebecca P. Payne,

Stephanie Longet,

James Austin,

Donal Skelly,

Wanwisa Dejnirattisai,

Sandra Adele,

Naomi Meardon,

Sian Faustini,

Saly AlTaei,

Shona C. Moore,

Tom Tipton,

Luisa M. Hering,

Adrienn Angyal,

Rebecca Brown,

Alexander R. Nicols,

Natalie Gillson,

Susan L. Dobson,

Ali Amini,

Piyada Supasa,

Andrew Cross,

Alice Bridges-Webb,

Laura Silva-Reyes,

Aline Linder,

Gurjinder Sandhar,

Jonathan A. Kilby,

Jessica K. Tyerman,

Thomas Altmann,

Hailey Hornsby,

Rachel Whitham,

Eloise Phillips,

Tom Malone,

Alexander Hargreaves,

Adrian M. Shields,

Ayoub Saei,

Sarah Foulkes,

Lizzie Stafford,

Síle A. Johnson,

Dan Wootton,

Christopher P. Conlon,

Katie Jeffery,

Philippa C. Matthews,

John Frater,

Alexandra Deeks,

Andrew J. Pollard,

Anthony Brown,

Sarah Rowland–Jones,

Juthathip Mongkolsapaya,

Eleanor Barnes,

Susan Hopkins,

Victoria Hall,

Christina Dold,

C.J. Duncan,

Alex Richter,

Miles W. Carroll,

Gavin Screaton,

Thushan I. de Silva,

Lance Turtle,

Paul Klenerman,

Susanna Dunachie,

Hibatullah Abuelgasim,

Emily Adland,

Syed Adlou,

Hossain Delowar Akther,

Ahmed Alhussni,

Mohammad Ali,

M. Azim Ansari,

Carolina V. Arancibia-Cárcamo,

Martin Bayley,

Helen Brown,

Jeremy Chalk,

Meera Chand,

Anu Chawla,

Senthil Chinnakannan,

Joseph Cutteridge,

Catherine de Lara,

Lucy Denly,

B. L. Diffey,

Stavros Dimitriadis,

Thomas M Drake,

Timothy Donnison,

Maeva Dupont,

David W. Eyre,

Alex Fairman,

Siobhan Gardiner,

Javier GilbertJaramillo,

Philip Goulder,

Carl-Philipp Hackstein,

Sophie Hambleton,

Muzlifah Haniffa,

Jenny Haworth,

Jennifer Holmes,

Emily C. Horner,

Anni Jämsén,

Christopher R. Jones,

Mwila Kasanyinga,

Sinéad Kelly,

Rosemary Kirk,

Michael L. Knight,

Allan Lawrie,

Lian Ni Lee,

Lauren Lett,

Katy Lillie,

Nicholas Lim,

Hema Mehta,

Alexander J. Mentzer,

Denise O’Donnell,

Ane Ogbe,

Matthew Pace,

Brendan Payne,

Gareth Platt,

Sonia Poolan,

Nicholas M. Provine,

Narayan Ramamurthy,

Nichola Robinson,

Leigh Romaniuk,

Patpong Rongkard,

Oliver Sampson,

Beatrice Simmons,

Jarmila Stremenova Spegarova,

Emily Stephenson,

Kris Subramaniam,

James Thaventhiran,

Sarah Thomas,

Simon Travis,

Stephanie Tucker,

H. Turton,

Adam Watson,

Lisa Watson,

Esme Weeks,

Robert Wilson,

Steven C. Wood,

Rachel Wright,

Huiyuan Xiao,

Amira Zawia

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.10.011

Subject(s) - immunogenicity , dosing , biology , regimen , antibody response , virology , covid-19 , neutralizing antibody , population , antibody , immunology , spike protein , medicine , pharmacology , environmental health , disease , infectious disease (medical specialty)

Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed this in a study of United Kingdom healthcare workers. The first vaccine dose induced protection from infection from the circulating alpha (B.1.1.7) variant over several weeks. In a substudy of 589 individuals, we show that this single dose induces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (NAb) responses and a sustained B and T cell response to the spike protein. NAb levels were higher after the extended dosing interval (6-14 weeks) compared with the conventional 3- to 4-week regimen, accompanied by enrichment of CD4 + T cells expressing interleukin-2 (IL-2). Prior SARS-CoV-2 infection amplified and accelerated the response. These data on dynamic cellular and humoral responses indicate that extension of the dosing interval is an effective immunogenic protocol.

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