Open AccesscAAVe phaenomena: Beware of appearances!
Author(s) -
Filippo Calzolari,
Benedikt Berninger
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.09.027
Subject(s) - biology , endogeny , neuroscience , microbiology and biotechnology , endocrinology
In this issue of Cell, Wang et al. come to the unsettling conclusion that adeno-associated viruses, despite being engineered for glia-specific expression, can become widely active in endogenous neurons, misleading researchers in their quest for efficient conversion of glia into neurons for brain repair.
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