Estrogen receptor gets a grip on RNA | Zendy

Benita S. Katzenellenbogen | Zendy

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Estrogen receptor gets a grip on RNA

Author(s) -

Benita S. Katzenellenbogen

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.09.012

Subject(s) - biology , estrogen receptor , estrogen receptor alpha , estrogen receptor beta , nuclear receptor , transcription factor , breast cancer , estrogen , cancer research , transcription (linguistics) , receptor , rna , rna binding protein , microbiology and biotechnology , cancer , genetics , gene , linguistics , philosophy

The nuclear hormone receptor estrogen receptor alpha (ERα) is a well-known transcription factor present in many breast cancers, where it promotes cancer progression. In this issue of Cell, Xu et al. report that ERα is also an RNA-binding protein and that its post-transcriptional activity enables cancer cell fitness and survival.

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