Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates | Zendy

Yun Chen | Zendy; Marco Colonna | Zendy

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Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates

Author(s) -

Yun Chen,

Marco Colonna

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.08.033

Subject(s) - microglia , biology , population , neuroscience , mitochondrion , microbiology and biotechnology , immunology , inflammation , environmental health , medicine

Microglia play critical roles in the defense against neurodegenerative diseases. In this issue of Cell, Scheiblich et al. focus on microglia that ingest toxic aggregates of α-synuclein, finding that α-synuclein-replete microglia exchange aggregates for healthy mitochondria via nanotube connections to unaffected microglia. This communication enables a shared approach to aggregates disposal while preserving the health of the microglial population.

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