Open AccessPartners with a killer: Metabolic signaling promotes inflammatory cell death
Author(s) -
Liu Z,
Tsan Sam Xiao
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.07.036
Subject(s) - biology , signal transduction , microbiology and biotechnology , inflammation , programmed cell death , immunology , apoptosis , genetics
In this issue of Cell, Evavold et al. (2021) report that mTOR Complex 1 (mTORC1), a metabolic signaling complex, controls reactive oxygen species (ROS) production in mitochondria, which in turn promotes inflammatory cell death mediated by gasdermin D (GSDMD). This provides a new mechanistic connection between metabolic signaling and inflammatory cell death.
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