Modeling neurodegeneration with mutant-tau organoids | Zendy

Laura Pellegrini | Zendy; Madeline A. Lancaster | Zendy

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Modeling neurodegeneration with mutant-tau organoids

Author(s) -

Laura Pellegrini,

Madeline A. Lancaster

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.07.031

Subject(s) - biology , neurodegeneration , organoid , mutant , neuroscience , microbiology and biotechnology , computational biology , genetics , disease , pathology , gene , medicine

Greater understanding of the events preceding neurodegeneration is needed to design effective preventive and therapeutic strategies. In this issue of Cell, Bowles et al. (2021) report cerebral organoids that reveal early events in frontotemporal dementia pathogenesis due to mutations in microtubule-associated protein tau (MAPT), shedding light on a novel mechanism involving abnormal splicing and glutamate signaling.

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