Open AccessPolyamine: A metabolic compass for T helper cell fate direction
Author(s) -
Hao Shi,
Hongbo Chi
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.07.012
Subject(s) - biology , compass , polyamine , microbiology and biotechnology , cell fate determination , genetics , transcription factor , gene , cartography , geography
Interplay between metabolic and epigenetic remodeling may be key to cell fate control. In this issue of Cell, Puleston et al. and Wagner et al. use metabolomic, computational, and genetic approaches to uncover that polyamine metabolism directs T helper cell lineage choices, epigenetic state, and pathogenic potential in inflammation.
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