Open AccessImmunological lessons from CD28 deficiency in humans
Author(s) -
Andreas Wieland,
Rafi Ahmed
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.06.014
Subject(s) - biology , cytomegalovirus , immunology , mutation , virology , virus , genetics , herpesviridae , viral disease , gene
In this issue of Cell, Casanova and colleagues examine three family members with a mutation that results in deficiency of the T cell co-stimulatory molecule CD28. These patients exhibit clinical symptoms due to human papillomavirus-2 and -4 infections, show increased levels of Epstein-Barr virus and cytomegalovirus in the blood, and respond poorly to vaccines.
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