Open AccessCommensals and immune cells speak in the language of endogenous retroviruses
Author(s) -
Paula F. Zamora,
Jennifer M. Bomberger
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.06.013
Subject(s) - biology , commensalism , immune system , endogenous retrovirus , endogeny , virology , immunology , genetics , bacteria , gene , genome , endocrinology
How the microbiome and mucosal environment mediate homeostatic immunity in the skin is not well understood. In this issue of Cell, Lima-Junior and colleagues report that skin commensal bacteria induce endogenous retrovirus (ERV) expression and antiviral immune responses in keratinocytes, favoring the priming of beneficial commensal-specific T cell subsets that promote tissue homeostasis.
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