Open AccessThe imitation game: How glioblastoma outmaneuvers immune attack
Author(s) -
Ilon Liu,
Olivia A. Hack,
Mariella G. Filbin
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.04.008
Subject(s) - biology , glioblastoma , immune system , imitation , cancer research , neuroscience , genetics
Immune evasion and resistance to immunotherapy mark major roadblocks in treating glioblastoma, the deadliest form of brain cancer. In this issue of Cell, Gangoso et al. demonstrate that the immune microenvironment drives glioblastoma cells to hijack myeloid-characteristic transcriptional and epigenetic circuits as a mode of immune evasion.
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