A cellular and spatial map of the choroid plexus across brain ventricles and ages | Zendy

Neil Dani | Zendy; Rebecca H. Herbst | Zendy; Cristin McCabe | Zendy; Gilad S. Green | Zendy; Karol Kaiser | Zendy; Joshua P. Head | Zendy; Jin Cui | Zendy; Frederick B. Shipley | Zendy; Ahram Jang | Zendy; Danielle Dionne | Zendy; Lan Nguyễn | Zendy; Christopher Rodman | Zendy; Samantha J. Riesenfeld | Zendy; Jan Procházka | Zendy; Michaela Procházková | Zendy; Radislav Sedláček | Zendy; Feng Zhang | Zendy; Vı́tězslav Bryja | Zendy; Orit Rozenblatt–Rosen | Zendy; Naomi Habib | Zendy; Aviv Regev | Zendy; Maria K. Lehtinen | Zendy

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A cellular and spatial map of the choroid plexus across brain ventricles and ages

Author(s) -

Neil Dani,

Rebecca H. Herbst,

Cristin McCabe,

Gilad S. Green,

Karol Kaiser,

Joshua P. Head,

Jin Cui,

Frederick B. Shipley,

Ahram Jang,

Danielle Dionne,

Lan Nguyễn,

Christopher Rodman,

Samantha J. Riesenfeld,

Jan Procházka,

Michaela Procházková,

Radislav Sedláček,

Feng Zhang,

Vı́tězslav Bryja,

Orit Rozenblatt–Rosen,

Naomi Habib,

Aviv Regev,

Maria K. Lehtinen

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.04.003

Subject(s) - biology , choroid plexus , lateral ventricles , anatomy , choroid , plexus , neuroscience , microbiology and biotechnology , central nervous system , retina

The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. We delineate diverse cell types, subtypes, cell states, and expression programs in epithelial and mesenchymal cells across ages and ventricles. In the developing ChP, we predict a common progenitor pool for epithelial and neuronal cells, validated by lineage tracing. Epithelial and fibroblast cells show regionalized expression by ventricle, starting at embryonic stages and persisting with age, with a dramatic transcriptional shift with maturation, and a smaller shift in each aged cell type. With aging, epithelial cells upregulate host-defense programs, and resident macrophages upregulate interleukin-1β (IL-1β) signaling genes. Our atlas reveals cellular diversity, architecture and signaling across ventricles during development, maturation, and aging of the ChP-brain barrier.

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