Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States | Zendy

Nicole L. Washington | Zendy; Karthik Gangavarapu | Zendy; Mark Zeller | Zendy; Alexandre Bolze | Zendy; Elizabeth T. Cirulli | Zendy; Kelly M. Schiabor Barrett | Zendy; Brendan B. Larsen | Zendy; Catelyn Anderson | Zendy; Simon White | Zendy; Tyler Cassens | Zendy; Sharoni Jacobs | Zendy; Geraint Levan | Zendy; Jason Nguyen | Zendy; Jimmy M. Ramirez | Zendy; Charlotte Rivera-Garcia | Zendy; Efren Sandoval | Zendy; Xueqing Wang | Zendy; David Wong | Zendy; Emily Spencer | Zendy; Refugio RoblesSikisaka | Zendy; Ezra Kurzban | Zendy; Laura D. Hughes | Zendy; Xianding Deng | Zendy; Candace Wang | Zendy; Venice Servellita | Zendy; Holly Valentine | Zendy; Peter De Hoff | Zendy; Phoebe Seaver | Zendy; Shashank Sathe | Zendy; Kimberly Gietzen | Zendy; Brad Sickler | Zendy; Jay Antico | Zendy; Kelly Hoon | Zendy; Jianwen Liu | Zendy; Aaron Harding | Zendy; Omid Bakhtar | Zendy; Tracy Basler | Zendy; Brett Austin | Zendy; Duncan MacCannell | Zendy; Magnus Isaksson | Zendy; Phillip G. Febbo | Zendy; David G. Becker | Zendy; Marc Laurent | Zendy; Eric McDonald | Zendy; G Yeo | Zendy; Rob Knight | Zendy; Louise C. Laurent | Zendy; Eileen de Feo | Zendy; Michael Worobey | Zendy; Charles Y. Chiu | Zendy; Marc A. Suchard | Zendy; James T. Lu | Zendy; William Lee | Zendy; Kristian G. Andersen | Zendy

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Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States

Author(s) -

Nicole L. Washington,

Karthik Gangavarapu,

Mark Zeller,

Alexandre Bolze,

Elizabeth T. Cirulli,

Kelly M. Schiabor Barrett,

Brendan B. Larsen,

Catelyn Anderson,

Simon White,

Tyler Cassens,

Sharoni Jacobs,

Geraint Levan,

Jason Nguyen,

Jimmy M. Ramirez,

Charlotte Rivera-Garcia,

Efren Sandoval,

Xueqing Wang,

David Wong,

Emily Spencer,

Refugio RoblesSikisaka,

Ezra Kurzban,

Laura D. Hughes,

Xianding Deng,

Candace Wang,

Venice Servellita,

Holly Valentine,

Peter De Hoff,

Phoebe Seaver,

Shashank Sathe,

Kimberly Gietzen,

Brad Sickler,

Jay Antico,

Kelly Hoon,

Jianwen Liu,

Aaron Harding,

Omid Bakhtar,

Tracy Basler,

Brett Austin,

Duncan MacCannell,

Magnus Isaksson,

Phillip G. Febbo,

David G. Becker,

Marc Laurent,

Eric McDonald,

G Yeo,

Rob Knight,

Louise C. Laurent,

Eileen de Feo,

Michael Worobey,

Charles Y. Chiu,

Marc A. Suchard,

James T. Lu,

William Lee,

Kristian G. Andersen

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.03.052

Subject(s) - biology , transmission (telecommunications) , covid-19 , transmission rate , virology , demography , genetics , disease , medicine , sociology , outbreak , infectious disease (medical specialty) , electrical engineering , engineering

The highly transmissible B.1.1.7 variant of SARS-CoV-2, first identified in the United Kingdom, has gained a foothold across the world. Using S gene target failure (SGTF) and SARS-CoV-2 genomic sequencing, we investigated the prevalence and dynamics of this variant in the United States (US), tracking it back to its early emergence. We found that, while the fraction of B.1.1.7 varied by state, the variant increased at a logistic rate with a roughly weekly doubling rate and an increased transmission of 40%-50%. We revealed several independent introductions of B.1.1.7 into the US as early as late November 2020, with community transmission spreading it to most states within months. We show that the US is on a similar trajectory as other countries where B.1.1.7 became dominant, requiring immediate and decisive action to minimize COVID-19 morbidity and mortality.

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