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Founder cells shape brain evolution
Author(s) -
Jing Liu,
Debra L. Silver
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.03.045
Subject(s) - biology , human brain , neuroscience , cerebral cortex , progenitor , biological evolution , human evolution , organoid , neuroepithelial cell , evolutionary biology , cortex (anatomy) , progenitor cell , stem cell , microbiology and biotechnology , neural stem cell , genetics
Humans have an extraordinarily expanded and complex cerebral cortex, relative to non-human primates. Yet the mechanisms underlying cortical differences across evolution are unclear. A new study by Benito-Kwiecinski et al. employs cerebral organoids derived across great apes to implicate neuroepithelial progenitor shape transitions in human cortical expansion.

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